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Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins

Parainfluenza virus 5 (PIV5) is an enveloped, single-stranded, negative-sense RNA virus of the Paramyxoviridae family. PIV5 fusion and entry are mediated by the coordinated action of the receptor-binding protein, hemagglutinin–neuraminidase (HN), and the fusion protein (F). Upon triggering by HN, F...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Song, Albert S., Poor, Taylor A., Abriata, Luciano A., Jardetzky, Theodore S., Dal Peraro, Matteo, Lamb, Robert A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941503/
https://ncbi.nlm.nih.gov/pubmed/27335462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608349113
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