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Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
The p53–Mdm2 system is key to tumor suppression. We have recently reported that p53 as well as Mdm2 are capable of supporting DNA replication fork progression. On the other hand, we found that Mdm2 is a modifier of chromatin, modulating polycomb repressor complex (PRC)-driven histone modifications....
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6275510/ https://ncbi.nlm.nih.gov/pubmed/30413623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809592115 |
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