Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression

Knockdown of orexin/hypocretin 2 receptor (Orx(2)) in the basolateral amygdala (BLA) affects anxious and depressive behavior. We use a new behavioral paradigm, the Stress-Alternatives Model (SAM), designed to improve translational impact. The SAM induces social stress in adult male mice by aggressio...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Staton, Clarissa D., Yaeger, Jazmine D. W., Khalid, Delan, Haroun, Fadi, Fernandez, Belissa S., Fernandez, Jessica S., Summers, Bali K., Summers, Tangi R., Sathyanesan, Monica, Newton, Samuel S., Summers, Cliff H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6275094/
https://ncbi.nlm.nih.gov/pubmed/30240784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.09.016
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