Genome-wide meta-analysis of SNP-by-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry

We evaluated interactions of SNP-by-ACE-I/ARB and SNP-by-TD on serum potassium (K+) among users of antihypertensive treatments (anti-HTN). Our study included 7 European-ancestry (EA) (N=4835) and 4 African-ancestry (AA) cohorts (N=2016). We performed race-stratified, fixed-effect, inverse-variance-w...

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Publicado no:Pharmacogenomics J
Main Authors: Irvin, Marguerite R, Sitlani, Colleen M, Noordam, Raymond, Avery, Christie L, Bis, Joshua C, Floyd, James S, Li, Jin, Limdi, Nita A, Srinivasasainagendra, Vinodh, Stewart, James, de Mutsert, Renée, Mook-Kanamori, Dennis O, Lipovich, Leonard, Kleinbrink, Erica L, Smith, Albert, Bartz, Traci M, Whitsel, Eric A, Uitterlinden, Andre G, Wiggins, Kerri L, Wilson, James G, Zhi, Degui, Stricker, Bruno H, Rotter, Jerome I, Arnett, Donna K, Psaty, Bruce M, Lange, Leslie A
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274589/
https://ncbi.nlm.nih.gov/pubmed/29855607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-018-0021-9
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