Genome-wide meta-analysis of SNP-by-ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European and African ancestry

We evaluated interactions of SNP-by-ACE-I/ARB and SNP-by-TD on serum potassium (K+) among users of antihypertensive treatments (anti-HTN). Our study included 7 European-ancestry (EA) (N=4835) and 4 African-ancestry (AA) cohorts (N=2016). We performed race-stratified, fixed-effect, inverse-variance-w...

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izdano v:Pharmacogenomics J
Main Authors: Irvin, Marguerite R, Sitlani, Colleen M, Noordam, Raymond, Avery, Christie L, Bis, Joshua C, Floyd, James S, Li, Jin, Limdi, Nita A, Srinivasasainagendra, Vinodh, Stewart, James, de Mutsert, Renée, Mook-Kanamori, Dennis O, Lipovich, Leonard, Kleinbrink, Erica L, Smith, Albert, Bartz, Traci M, Whitsel, Eric A, Uitterlinden, Andre G, Wiggins, Kerri L, Wilson, James G, Zhi, Degui, Stricker, Bruno H, Rotter, Jerome I, Arnett, Donna K, Psaty, Bruce M, Lange, Leslie A
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274589/
https://ncbi.nlm.nih.gov/pubmed/29855607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-018-0021-9
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