Interaction of Di-2-pyridylketone 2-pyridine Carboxylic Acid Hydrazone and Its Copper Complex with BSA: Effect on Antitumor Activity as Revealed by Spectroscopic Studies

The drug, di-2-pyridylketone-2-pyridine carboxylic acid hydrazone (DPPCAH) and its copper complex (DPPCAH-Cu) exhibit significant antitumor activity. However, the mechanism of their pharmacological interaction with the biological molecule bovine serum albumin (BSA) remains poorly understood. The pre...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Li, Cuiping, Huang, Tengfei, Fu, Yun, Liu, Youxun, Zhou, Sufeng, Qi, Zhangyang, Li, Changzheng
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6274005/
https://ncbi.nlm.nih.gov/pubmed/27136517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21050563
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