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Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals

Protease inhibitors are key components in the chemotherapy of HIV infection. However, the appearance of viral mutants routinely compromises their clinical efficacy, creating a constant need for new and more potent inhibitors. Recently, a new class of epoxide-based inhibitors of HIV-1 protease was in...

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Bibliografiska uppgifter
I publikationen:Molecules
Huvudupphovsmän: Olajuyigbe, Folasade M., Demitri, Nicola, De Zorzi, Rita, Geremia, Silvano
Materialtyp: Artigo
Språk:Inglês
Publicerad: MDPI 2016
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273989/
https://ncbi.nlm.nih.gov/pubmed/27809253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21111458
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