Impact of Stereochemistry on Ligand Binding: X-ray Crystallographic Analysis of an Epoxide-Based HIV Protease Inhibitor

[Image: see text] A new pseudopeptide epoxide inhibitor, designed for irreversible binding to HIV protease (HIV-PR), has been synthesized and characterized in solution and in the solid state. However, the crystal structure of the complex obtained by inhibitor–enzyme cocrystallization revealed that a...

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Detalhes bibliográficos
Main Authors: Benedetti, Fabio, Berti, Federico, Campaner, Pietro, Fanfoni, Lidia, Demitri, Nicola, Olajuyigbe, Folasade M., De March, Matteo, Geremia, Silvano
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160752/
https://ncbi.nlm.nih.gov/pubmed/25221650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500092e
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