Antileishmanial Activity and Structure-Activity Relationship of Triazolic Compounds Derived from the Neolignans Grandisin, Veraguensin, and Machilin G

Sixteen 1,4-diaryl-1,2,3-triazole compounds 4–19 derived from the tetrahydrofuran neolignans veraguensin 1, grandisin 2, and machilin G 3 were tested against Leishmania (Leishmania) amazonensis intracellular amastigotes. Triazole compounds 4–19 were synthetized via Click Chemistry strategy by 1,3-di...

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Publié dans:Molecules
Auteurs principaux: Costa, Eduarda C., Cassamale, Tatiana B., Carvalho, Diego B., Bosquiroli, Lauriane S. S., Ojeda, Mariáh, Ximenes, Thalita V., Matos, Maria F. C., Kadri, Mônica C. T., Baroni, Adriano C. M., Arruda, Carla C. P.
Format: Artigo
Langue:Inglês
Publié: MDPI 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273954/
https://ncbi.nlm.nih.gov/pubmed/27331807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21060802
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