Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives

A FRET-based random screening assay was used to generate hit compounds as sortase A inhibitors that allowed us to identify ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate as an example of a new class of sortase A inhibitors. Other analogues were generated by changing the ethoxycarbonyl function for...

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Gepubliceerd in:Molecules
Hoofdauteurs: Maggio, Benedetta, Raffa, Demetrio, Raimondi, Maria Valeria, Cascioferro, Stella, Plescia, Fabiana, Schillaci, Domenico, Cusimano, Maria Grazia, Leonchiks, Ainars, Zhulenkovs, Dmitrijs, Basile, Livia, Daidone, Giuseppe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273394/
https://ncbi.nlm.nih.gov/pubmed/26907235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21020241
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