Celecoxib for the Prevention of Colorectal Adenomas: Results of a Suspended Randomized Controlled Trial

BACKGROUND: Cyclooxygenase (COX)-2 inhibitors such as celecoxib were designed to preserve anti-inflammatory activity without inhibiting COX-1. Downregulation of COX-2 inhibits colorectal carcinogenesis. METHODS: The Selenium and Celecoxib Trial was a randomized, placebo-controlled trial of once-dail...

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Veröffentlicht in:J Natl Cancer Inst
Hauptverfasser: Thompson, Patricia A, Ashbeck, Erin L, Roe, Denise J, Fales, Liane, Buckmeier, Julie, Wang, Fang, Bhattacharyya, Achyut, Hsu, Chiu-Hsieh, Chow, Sherry H H, Ahnen, Dennis J, Boland, C Richard, Heigh, Russell I, Fay, David E, Hamilton, Stanley R, Jacobs, Elizabeth T, Martinez, Elena Maria, Alberts, David S, Lance, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272806/
https://ncbi.nlm.nih.gov/pubmed/27530656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djw151
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