In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease

BACKGROUND: Liver disease (LD) prolongs mirtazapine half‐life in humans, but it is unknown if this occurs in cats with LD and healthy cats. HYPOTHESIS/OBJECTIVES: To determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver microsomes) in cats with LD and healthy cats...

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Bibliografske podrobnosti
izdano v:J Vet Intern Med
Main Authors: Fitzpatrick, Rikki L., Quimby, Jessica M., Benson, Kellyi K., Ramirez, Dominique, Sieberg, Liberty G., Wittenburg, Luke A., Gustafson, Daniel L.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
SMALL ANIMAL
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272035/
https://ncbi.nlm.nih.gov/pubmed/30307637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jvim.15237
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