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Synthesis and Antifungal Activity of Novel Triazole Compounds Containing Piperazine Moiety

Design and synthesis of triazole library antifungal agents having piperazine side chains, analogues to fluconazole were documented. The synthesis highlighted utilization of the click chemistry on the basis of the active site of the cytochrome P450 14α-demethylase (CYP51). Their structures were chara...

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Publicado en:Molecules
Autores principales: Wang, Yanwei, Xu, Kehan, Bai, Guojing, Huang, Lei, Wu, Qiuye, Pan, Weihua, Yu, Shichong
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271785/
https://ncbi.nlm.nih.gov/pubmed/25090121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules190811333
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