Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

A number of novel spiro-pyrrolidines/pyrrolizines derivatives were synthesized through [3+2]-cycloaddition of azomethine ylides with 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones 2a–n. Azomethine ylides were generated in situ from the reaction of 1H-indole-2,3-dione (isatin, 3) with N-met...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Almansour, Abdulrahman I., Kumar, Raju Suresh, Beevi, Farzana, Nasrolahi Shirazi, Amir, Osman, Hasnah, Ismail, Rusli, Choon, Tan Soo, Sullivan, Brian, McCaffrey, Kellen, Nahhas, Alaa, Parang, Keykavous, Ali, Mohamed Ashraf
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6271256/
https://ncbi.nlm.nih.gov/pubmed/25014532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules190710033
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