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Synthesis and Relaxivity Studies of a DOTA-Based Nanomolecular Chelator Assembly Supported by an Icosahedral Closo-B(12)(2−) -Core for MRI: A Click Chemistry Approach
An icosahedral closo-B(12)(2−) scaffold based nano-sized assembly capable of carrying a high payload of Gd(3+)-chelates in a sterically crowded configuration is developed by employing the azide-alkyne click reaction. The twelve copies of DO3A-t-Bu-ester ligands were covalently attached to an icosahe...
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| Publicado no: | Molecules |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6270972/ https://ncbi.nlm.nih.gov/pubmed/23899836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18089034 |
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