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cRGD Peptide-Conjugated Icosahedral closo-B(12) (2−) Core Carrying Multiple Gd(3+)-DOTA Chelates for α(v)β(3) Integrin-Targeted Tumor Imaging (MRI)
A vertex-differentiated icosahedral closo-B(12)(2−) core was utilized to construct a α(v)β(3) integrin receptor-targeted (via cRGD peptide) high payload MRI contrast agent (CA-12) carrying 11 copies of Gd(3+)-DOTA chelates attached to the closo-B(12)(2−) surface via suitable linkers. The resulting p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593306/ https://ncbi.nlm.nih.gov/pubmed/23391150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic302340c |
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