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Synthesis and Evaluation of Some 17-Acetamidoandrostane and N,N-Dimethyl-7-deoxycholic Amide Derivatives as Cytotoxic Agents: Structure/Activity Studies

Using pregnenolone and 7-deoxycholic acid as starting materials, some 17-acetamidoandrostane and N,N-dimethyl-7-deoxycholic amide derivatives were synthesized. The cytotoxicity of the synthesized compounds was tested in vitro against two tumor cell lines: SGC 7901 (human gastric carcinoma) and Bel 7...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Huang, Yanmin, Cui, Jianguo, Jia, Linyi, Gan, Chunfang, Song, Huacan, Zeng, Chun, Zhou, Aimin
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270639/
https://ncbi.nlm.nih.gov/pubmed/23803715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18077436
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