Facile and Efficient Syntheses of a Series of N-Benzyl and N-Biphenylmethyl Substituted Imidazole Derivatives Based on (E)-Urocanic acid, as Angiotensin II AT1 Receptor Blockers

In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have revealed that N-substituted imidazole derivatives based on (E)-urocanic acid may be potential antihypertensive leads. Therefore, new AT1 receptor...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Agelis, George, Kelaidonis, Konstantinos, Resvani, Amalia, Kalavrizioti, Dimitra, Androutsou, Maria-Eleni, Plotas, Panagiotis, Vlahakos, Demetrios, Koukoulitsa, Catherine, Tselios, Theodore, Mavromoustakos, Thomas, Matsoukas, John
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6270370/
https://ncbi.nlm.nih.gov/pubmed/23807577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18077510
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