Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

α-catenin is a key mechanosensor that forms force-dependent interactions with F-actin, thereby coupling the cadherin-catenin complex to the actin cytoskeleton at adherens junctions (AJs). However, the molecular mechanisms by which α-catenin engages F-actin under tension remained elusive. Here we sho...

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Publicado en:Nat Commun
Autores principales: Ishiyama, Noboru, Sarpal, Ritu, Wood, Megan N., Barrick, Samantha K., Nishikawa, Tadateru, Hayashi, Hanako, Kobb, Anna B., Flozak, Annette S., Yemelyanov, Alex, Fernandez-Gonzalez, Rodrigo, Yonemura, Shigenobu, Leckband, Deborah E., Gottardi, Cara J., Tepass, Ulrich, Ikura, Mitsuhiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269467/
https://ncbi.nlm.nih.gov/pubmed/30504777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07481-7
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