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Benzoylated Uronic Acid Building Blocks and Synthesis of N-Uronate Conjugates of Lamotrigine

A chemoenzymatic approach towards benzoylated uronic acid building blocks has been investigated starting with benzoylated hexapyranosides using regioselective C-6 enzymatic hydrolysis as the key step. Two of the building blocks were reacted with the antiepileptic drug lamotrigine. Glucuronidation of...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Esmurziev, Aslan M., Reimers, Arne, Andreassen, Trygve, Simic, Nebojsa, Sundby, Eirik, Hoff, Bård Helge
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268592/
https://ncbi.nlm.nih.gov/pubmed/22269868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17010820
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