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One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties

The well-known Ugi reaction of aldehydes with amines, carboxylic acids and isocyanides leads to the formation of acyclic α-acylaminocarboxamides. Replacement of the carboxylic acid derivatives with β-acyl substituted acrylic acids gives access to highly substituted 2,5-diketopiperazines in one singl...

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Detalles Bibliográficos
Publicado en:Molecules
Main Authors: Hartung, Andreas, Seufert, Florian, Berges, Carsten, Gessner, Viktoria H., Holzgrabe, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6268348/
https://ncbi.nlm.nih.gov/pubmed/23519247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules171214685
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