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GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy
BACKGROUND: Ligand-dependent activation of the G-protein coupled receptor 119 (GPR119) lowers blood glucose via glucose-dependent insulin secretion and intestinal glucagon-like peptide-1 production. However, the function of GPR119 in cancer cells has not been studied. METHODS: GPR119 expression was...
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| Veröffentlicht in: | J Exp Clin Cancer Res |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6267899/ https://ncbi.nlm.nih.gov/pubmed/30497501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0949-2 |
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