GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy

BACKGROUND: Ligand-dependent activation of the G-protein coupled receptor 119 (GPR119) lowers blood glucose via glucose-dependent insulin secretion and intestinal glucagon-like peptide-1 production. However, the function of GPR119 in cancer cells has not been studied. METHODS: GPR119 expression was...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Im, Ji Hye, Kang, Keon Wook, Kim, Sun Young, Kim, Yoon Gyoon, An, Yong Jin, Park, Sunghyouk, Jeong, Byung Hwa, Choi, Song-Yi, Lee, Jin-Sun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6267899/
https://ncbi.nlm.nih.gov/pubmed/30497501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0949-2
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