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Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S...
Gardado en:
| Publicado en: | Mar Drugs |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6266488/ https://ncbi.nlm.nih.gov/pubmed/30373260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16110413 |
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