In Vivo Evaluation of a New Recombinant Hyaluronidase to Improve Gene Electro-Transfer Protocols for DNA-Based Drug Delivery against Cancer

Cancer vaccines based on plasmid DNA represent a good therapeutic perspective, despite their low potency. Animal-derived hyaluronidases (Hyals) are employed in oncological clinical practice. Hyal has been also demonstrated to be a good enhancer of intramuscular Gene Electro-Transfer (GET) efficiency...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: De Robertis, Mariangela, Pasquet, Lise, Loiacono, Luisa, Bellard, Elisabeth, Messina, Luciano, Vaccaro, Susanna, Di Pasquale, Roberta, Fazio, Vito Michele, Rols, Marie-Pierre, Teissie, Justin, Golzio, Muriel, Signori, Emanuela
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265783/
https://ncbi.nlm.nih.gov/pubmed/30373297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers10110405
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