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NMR structure of a G-quadruplex formed by four d(G(4)C(2)) repeats: insights into structural polymorphism

Most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), is a largely increased number of d(G(4)C(2))n•(G(2)C(4))n repeats located in the non-coding region of C9orf72 gene. Non-canonical structures, including G-quadruplexes, formed within expanded repeats...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Brčić, Jasna, Plavec, Janez
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6265483/
https://ncbi.nlm.nih.gov/pubmed/30277522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky886
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