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Synthesis and SAR Study of Novel Peptide Aldehydes as Inhibitors of 20S Proteasome
Based on the analysis of the crystal structure of MG101 (1) and 20S proteasomes, a new series of peptide aldehyde derivatives were designed and synthesized. Their ability to inhibit 20S proteasome was assayed. Among them, Cbz-Glu(OtBu)-Phe-Leucinal (3c), Cbz-Glu(OtBu)-Leu-Leucinal (3d), and Boc-Ser(...
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| Publicado en: | Molecules |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
MDPI
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6264673/ https://ncbi.nlm.nih.gov/pubmed/21894088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16097551 |
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