Short telomere syndromes cause a primary T cell immunodeficiency

The mechanisms that drive T cell aging are not understood. We report that children and adult telomerase mutation carriers with short telomere length (TL) develop a T cell immunodeficiency that can manifest in the absence of bone marrow failure and causes life-threatening opportunistic infections. Mu...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wagner, Christa L., Hanumanthu, Vidya Sagar, Talbot, C. Conover, Abraham, Roshini S., Hamm, David, Gable, Dustin L., Kanakry, Christopher G., Applegate, Carolyn D., Siliciano, Janet, Jackson, J. Brooks, Desiderio, Stephen, Alder, Jonathan K., Luznik, Leo, Armanios, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264634/
https://ncbi.nlm.nih.gov/pubmed/30179220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120216
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