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Short telomere syndromes cause a primary T cell immunodeficiency

The mechanisms that drive T cell aging are not understood. We report that children and adult telomerase mutation carriers with short telomere length (TL) develop a T cell immunodeficiency that can manifest in the absence of bone marrow failure and causes life-threatening opportunistic infections. Mu...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Clin Invest
Main Authors: Wagner, Christa L., Hanumanthu, Vidya Sagar, Talbot, C. Conover, Abraham, Roshini S., Hamm, David, Gable, Dustin L., Kanakry, Christopher G., Applegate, Carolyn D., Siliciano, Janet, Jackson, J. Brooks, Desiderio, Stephen, Alder, Jonathan K., Luznik, Leo, Armanios, Mary
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264634/
https://ncbi.nlm.nih.gov/pubmed/30179220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120216
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