Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties

Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at t...

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Veröffentlicht in:Molecules
Hauptverfasser: Jin, Yun-Zhou, Fu, Da-Xu, Ma, Nan, Li, Zhan-Cheng, Liu, Quan-Hai, Xiao, Lin, Zhang, Rong-Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264549/
https://ncbi.nlm.nih.gov/pubmed/22068619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16119368
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