In silico identification and experimental validation of hits active against KPC-2 β-lactamase

Bacterial resistance has become a worldwide concern, particularly after the emergence of resistant strains overproducing carbapenemases. Among these, the KPC-2 carbapenemase represents a significant clinical challenge, being characterized by a broad substrate spectrum that includes aminothiazoleoxim...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Klein, Raphael, Linciano, Pasquale, Celenza, Giuseppe, Bellio, Pierangelo, Papaioannou, Sofia, Blazquez, Jesus, Cendron, Laura, Brenk, Ruth, Tondi, Donatella
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264499/
https://ncbi.nlm.nih.gov/pubmed/30496182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0203241
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