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Synthesis of Key Fragments of Amphidinolide Q — A Cytotoxic 12-membered Macrolide

β-Hydroxy aldehyde and alkyl ketone moieties were effectively synthesized as key intermediates of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp.. The asymmetric center of the former derivative was produced by Sharpless asymmetric epoxidation, followed by E-se...

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Bibliografische gegevens
Gepubliceerd in:Molecules
Hoofdauteurs: Kawa, Kohei, Hara, Akihiro, Ishikawa, Yuichi, Nishiyama, Shigeru
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264435/
https://ncbi.nlm.nih.gov/pubmed/21709623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16075422
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