Ru/Me-BIPAM-Catalyzed Asymmetric Addition of Arylboronic Acids to Aliphatic Aldehydes and α-Ketoesters

A ruthenium-catalyzed asymmetric arylation of aliphatic aldehydes and α-ketoesters with arylboronic acids has been developed, giving chiral alkyl(aryl)methanols and α-hydroxy esters in good yields. The use of a chiral bidentate phosphoramidite ligand (Me-BIPAM) achieved excellent enantioselectivitie...

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Bibliographic Details
Published in:Molecules
Main Authors: Yamamoto, Yasunori, Shirai, Tomohiko, Watanabe, Momoko, Kurihara, Kazunori, Miyaura, Norio
Format: Artigo
Language:Inglês
Published: MDPI 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264355/
https://ncbi.nlm.nih.gov/pubmed/21694668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16065020
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