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Schiff Bases of Indoline-2,3-dione: Potential Novel Inhibitors of Mycobacterium Tuberculosis (Mtb) DNA Gyrase (†)

In the present study a series of Schiff bases of indoline-2,3-dione were synthesized and investigated for their Mtb gyrase inhibitory activity. Promising inhibitory activity was demonstrated with some of these derivatives, which exhibited IC(50) values ranging from 50–157 μM. The orientation and the...

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Bibliografiske detaljer
Udgivet i:Molecules
Main Authors: Aboul-Fadl, Tarek, Abdel-Aziz, Hatem A., Abdel-Hamid, Mohammed K., Elsaman, Tilal, Thanassi, Jane, Pucci, Michael J.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264139/
https://ncbi.nlm.nih.gov/pubmed/22143547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16097864
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