Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine

Immune checkpoint blockade (ICB) therapies, which potentiate the body’s natural immune response against tumor cells, have shown immense promise in the treatment of various cancers. Currently, tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are the primary biomarkers ev...

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Bibliografiske detaljer
Udgivet i:Genome Med
Main Authors: Conway, Jake R., Kofman, Eric, Mo, Shirley S., Elmarakeby, Haitham, Van Allen, Eliezer
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264032/
https://ncbi.nlm.nih.gov/pubmed/30497521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0605-7
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