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Discovery of Benzothiazole Amides as Potent Antimycobacterial Agents

From a high throughput screening of commercially available libraries against nontuberculous mycobacteria and Mycobacterium tuberculosis, numerous hits were identified with moderate activity. Extensive medicinal chemistry optimization has led to a series of potent benzothiazole amide antimycobacteria...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Graham, James, Wong, Christina E., Day, Joshua, McFaddin, Elizabeth, Ochsner, Urs, Hoang, Teresa, Young, Casey L., Ribble, Wendy, DeGroote, Mary A., Jarvis, Thale, Sun, Xicheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263154/
https://ncbi.nlm.nih.gov/pubmed/30172617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.08.026
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