EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation

Aims: The aim of this study was to reveal the specific molecular mechanisms by which DENND1A accepts EGF signaling and activates Rab35 in gastric cancer. Methods: The expression of proteins related to DENND1A was examined by western blot analysis. Activation of Rab35 was assessed by GST-pulldown. Th...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Ye, Bixing, Duan, Biao, Deng, Wenjie, Wang, Yueyuan, Chen, Yan, Cui, Jie, Sun, Shixiu, Zhang, Yujie, Du, Jun, Gu, Luo, Lin, Lin, Tang, Yurong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261971/
https://ncbi.nlm.nih.gov/pubmed/30524285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01343
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