ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence

p63 and c-Myc are key transcription factors controlling genes involved in the cell cycle and cellular senescence. We previously reported that p63α can destabilize MM1 protein to derepress c-Myc, resulting in cell cycle progress and tumorigenesis. However, how the proteasomal degradation of MM1 is fa...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Chen, Yonglong, Li, Yimin, Peng, Yougong, Zheng, Xuan, Fan, Shijie, Yi, Yong, Zeng, Peng, Chen, Hu, Kang, Han, Zhang, Yujun, Xiao, Zhi-Xiong, Li, Chenghua
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261956/
https://ncbi.nlm.nih.gov/pubmed/29880857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0132-5
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