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A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo

Botulinum neurotoxin (BoNT) is a major therapeutic agent. Of seven native BoNT serotypes (A to G), only A and B are currently used in the clinic. Here we compared the potency of commercially available purified native serotypes A1 to F1 across in vitro, ex vivo, and in vivo assays. BoNT potency in vi...

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Détails bibliographiques
Publié dans:Pharmacol Res Perspect
Auteurs principaux: Donald, Sarah, Elliott, Mark, Gray, Bryony, Hornby, Fraser, Lewandowska, Agnieszka, Marlin, Sandra, Favre‐Guilmard, Christine, Périer, Cindy, Cornet, Sylvie, Kalinichev, Mikhail, Krupp, Johannes, Fonfria, Elena
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261930/
https://ncbi.nlm.nih.gov/pubmed/30519475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.446
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