A comparison of biological activity of commercially available purified native botulinum neurotoxin serotypes A1 to F1 in vitro, ex vivo, and in vivo

Botulinum neurotoxin (BoNT) is a major therapeutic agent. Of seven native BoNT serotypes (A to G), only A and B are currently used in the clinic. Here we compared the potency of commercially available purified native serotypes A1 to F1 across in vitro, ex vivo, and in vivo assays. BoNT potency in vi...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Donald, Sarah, Elliott, Mark, Gray, Bryony, Hornby, Fraser, Lewandowska, Agnieszka, Marlin, Sandra, Favre‐Guilmard, Christine, Périer, Cindy, Cornet, Sylvie, Kalinichev, Mikhail, Krupp, Johannes, Fonfria, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261930/
https://ncbi.nlm.nih.gov/pubmed/30519475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.446
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