Synthetic STARR-seq reveals how DNA shape and sequence modulate transcriptional output and noise

The binding of transcription factors to short recognition sequences plays a pivotal role in controlling the expression of genes. The sequence and shape characteristics of binding sites influence DNA binding specificity and have also been implicated in modulating the activity of transcription factors...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Genet
Hauptverfasser: Schöne, Stefanie, Bothe, Melissa, Einfeldt, Edda, Borschiwer, Marina, Benner, Philipp, Vingron, Martin, Thomas-Chollier, Morgane, Meijsing, Sebastiaan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261644/
https://ncbi.nlm.nih.gov/pubmed/30427832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007793
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