T cell intrinsic Receptor Interacting Protein 2 regulates pathogenic T helper-17 cell differentiation

Receptor Interacting Protein 2 (RIP2) plays a role in sensing intracellular pathogens, but its function in T cells is unclear. We show that RIP2 deficiency in CD4(+) T cells resulted in chronic and severe interleukin-17A mediated inflammation during Chlamydia pneumoniae lung infection, increased T h...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Shimada, Kenichi, Porritt, Rebecca A., Markman, Janet L., Gire O’rourke, Jacqueline, Wakita, Daiko, Noval Rivas, Magali, Ogawa, Chihiro, Kozhaya, Lina, Martins, Gislâine A., Unutmaz, Derya, Baloh, Robert H., Crother, Timothy R., Chen, Shuang, Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260980/
https://ncbi.nlm.nih.gov/pubmed/30366765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.08.022
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