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A close look onto structural models and primary ligands of metallo-β-lactamases
β-Lactamases are hydrolytic enzymes capable of opening the β-lactam ring of antibiotics such as penicillin, thus endowing the bacteria that produce them with antibiotic resistance. Of particular medical concern are metallo-β-lactamases (MBLs), with an active site built around coordinated Zn cations....
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| Publicado no: | Drug Resist Updat |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6260963/ https://ncbi.nlm.nih.gov/pubmed/30466711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drup.2018.08.001 |
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