Heme oxygenase‐1 induction attenuates senescence in chronic obstructive pulmonary disease lung fibroblasts by protecting against mitochondria dysfunction

Chronic obstructive pulmonary disease (COPD) is associated with lung fibroblast senescence, a process characterized by an irreversible proliferation arrest associated with secretion of inflammatory mediators. ROS production, known to induce senescence, is increased in COPD fibroblasts and mitochondr...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Even, Benjamin, Fayad‐Kobeissi, Sarah, Gagliolo, Jean‐Marie, Motterlini, Roberto, Boczkowski, Jorge, Foresti, Roberta, Dagouassat, Maylis
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260925/
https://ncbi.nlm.nih.gov/pubmed/30341816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12837
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