The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for >30,000 deaths annually. Although somatic activating mutations in KRAS appear in 97% of PDAC patients, additional factors are required to initiate PDAC. Because mutation...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cell Mol Gastroenterol Hepatol
Main Authors: Young, Claire C., Baker, Ryan M., Howlett, Christopher J., Hryciw, Todd, Herman, Joshua E., Higgs, Douglas, Gibbons, Richard, Crawford, Howard, Brown, Arthur, Pin, Christopher L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260375/
https://ncbi.nlm.nih.gov/pubmed/30510993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.09.004
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares