The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for >30,000 deaths annually. Although somatic activating mutations in KRAS appear in 97% of PDAC patients, additional factors are required to initiate PDAC. Because mutation...

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Опубликовано в: :Cell Mol Gastroenterol Hepatol
Главные авторы: Young, Claire C., Baker, Ryan M., Howlett, Christopher J., Hryciw, Todd, Herman, Joshua E., Higgs, Douglas, Gibbons, Richard, Crawford, Howard, Brown, Arthur, Pin, Christopher L.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2018
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260375/
https://ncbi.nlm.nih.gov/pubmed/30510993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.09.004
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