Synthesis, Characterization and Pharmacological Evaluation of 1-(2-Chloro-6-Fluorophenyl)-5-Methylindolin-2-One: A New Anti-Inflammatory Compound with Reduced Gastric Ulceration Properties

The new compound 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one (1), designed using the prodrug approach, was easily obtained in 85% yield and characterized by nuclear magnetic resonance, elemental analysis, mass spectrometry and infrared spectroscopy. The lactam 1 showed anti-inflammatory and an...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Molecules
Egile Nagusiak: dos Santos, Jean Leandro, Chelucci, Rafael, Chiquetto, Richard, Chung, Man Chin, Campos, Michel Leandro, Peccinini, Rosangela Gonçalves
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: MDPI 2010
Gaiak:
Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6259214/
https://ncbi.nlm.nih.gov/pubmed/21060305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules15118039
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