Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties

The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 showed anti-inflammatory and analgesic activity without gastro-ulcerogenic effect...

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Vydáno v:Molecules
Hlavní autoři: Chung, Man Chin, dos Santos, Jean Leandro, Oliveira, Ednir Vizioli, Blau, Lorena, Menegon, Renato Farina, Peccinini, Rosângela Gonçalves
Médium: Artigo
Jazyk:Inglês
Vydáno: Molecular Diversity Preservation International 2009
Témata:
Communication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255044/
https://ncbi.nlm.nih.gov/pubmed/19783917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules14093187
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