Lysosomal Proteases Are a Determinant of Coronavirus Tropism

Cell entry by coronaviruses involves two principal steps, receptor binding and membrane fusion; the latter requires activation by host proteases, particularly lysosomal proteases. Despite the importance of lysosomal proteases in both coronavirus entry and cell metabolism, the correlation between lys...

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Bibliographic Details
Published in:J Virol
Main Authors: Zheng, Yuan, Shang, Jian, Yang, Yang, Liu, Chang, Wan, Yushun, Geng, Qibin, Wang, Michelle, Baric, Ralph, Li, Fang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258935/
https://ncbi.nlm.nih.gov/pubmed/30258004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01504-18
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