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Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus

To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allow...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Yang, Yang, Liu, Chang, Du, Lanying, Jiang, Shibo, Shi, Zhengli, Baric, Ralph S., Li, Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524054/
https://ncbi.nlm.nih.gov/pubmed/26063432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01279-15
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