Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix (ECM) fragmentation and inflammation. However, the mechanisms by which these events are coupled thereby fueling focal vascular damage are undefined. Here we report through single-cell RNA-sequencing of diseased aort...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Hadi, Tarik, Boytard, Ludovic, Silvestro, Michele, Alebrahim, Dornazsadat, Jacob, Samson, Feinstein, Jordyn, Barone, Krista, Spiro, Wes, Hutchison, Susan, Simon, Russell, Rateri, Debra, Pinet, Florence, Fenyo, David, Adelman, Mark, Moore, Kathryn J., Eltzschig, Holger K., Daugherty, Alan, Ramkhelawon, Bhama
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258757/
https://ncbi.nlm.nih.gov/pubmed/30479344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07495-1
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